Mysimba | Weight Loss Tablets

Buy Mysimba Weight Loss Online - Ashcroft Pharmacy UK
  • Buy Mysimba Weight Loss Online - Ashcroft Pharmacy UK

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Mysimba | Weight Loss Tablets

Fastest delivery:
Monday, 27 May 2024
  • Medication features

    1-Month Supply

    Mysimba is a doctors recommended (Rx) weight loss medication for obese. Proven weight loss treatment in adults who are overweight with weight-related health problems such as diabetes.

    • Lose weight in 2 ways
    • Reduces appetite and cravings
    • Boosts metabolism
    • Regulates unwanted weight gain
    • Take Mysimba with food
    • Do not exceed 4 tablets per day
    • Works best with diet/exercise
    • PIL

    Related Drug:

    These tablets are available in the UK and you can order Mysimba online through services like UK-registered Ashcroft Pharmacy.

    UK-registered Ashcroft Pharmacy
    Registered UK Pharmacy Number: 1039428

Order Monday to Friday before 14:00pm to guarantee next day delivery

Fastest delivery: Monday, 27 May 2024


NOTE: After selecting this product, you will need to complete a short assessment, so we can make sure this medication is suitable for you.

What is Mysimba?

Mysimba (POM) is a weight-loss tablet for adults with obesity (BMI over 30) or overweight (BMI 27-30) with weight-related health conditions like diabetes, high blood pressure or high cholesterol.

It combines two drugs, naltrexone and bupropion, to help reduce appetite and support weight loss when used with a doctor-recommended healthy diet and exercise plan.

BMI Definition: BMI is a measure of body weight in relation to height. Obesity in adults is defined as a BMI of 30 or higher. Overweight is defined as a BMI between 27 and less than 30.

What is Mysimba tablets used for?

Mysimba (prescription weight loss treatment) is used by overweight or obese adults, in conjunction with a reduced-calorie diet and increased physical activity, to support weight loss.

Approval for Use:

Mysimba is approved for use in patients with a BMI of 30 or higher. It can also be prescribed for those with a BMI between 27 and less than 30 if they have additional weight-related conditions such as high blood pressure (hypertension), type 2 diabetes, or high lipid (fat) levels in the blood.

Overweight & Obesity

To be considered overweight, an adult needs a BMI of at least 27kg/m2. For obesity, it's a BMI of at least 30kg/m2. Those with a BMI under 30kg/m2 may be eligible for the drug if they are at risk of weight-related problems.

If, after 16 weeks, the patient hasn't lost at least 5 percent of their starting weight, the doctor might stop giving them Mysimba.

Additionally, the doctor could recommend stopping Mysimba treatment if they are concerned about the patient's blood pressure increasing or other safety issues.

How does Mysimba work?

Struggling with constant cravings and feeling sluggish? Mysimba might be the solution that effective. Mysimba works differently from laxatives and stimulants. It doesn't directly affect your intestines' movements. Instead, it works on your brain.

It helps you by using two ingredients: naltrexone and bupropion. These ingredients work on your brain in two ways:

  • Naltrexone (opiate antagonists) reduces your desire for food ( less interested in food)
  • Bupropion (antidepressants) makes you feel fuller or more satisfied and boosts calorie burning

Together, they help reduce hunger and cravings, allowing you to eat smaller meals and avoid snacking on foods that could lead to weight gain. This makes it easier to stick to a healthy diet and lose weight.

About naltrexone and bupropion

Both naltrexone and bupropion have been used for over 30 years to treat other conditions, like quitting smoking, by controlling cravings.

Mysimba alternatives for weight loss

While Mysimba is a popular weight loss medication, it's not the only option out there. There are several alternatives to consider, such as:

  • Saxenda (injectable medicine)
  • Wegovy (semaglutide injection pen)
  • Orlistat (Branded weight loss hard capsules)
  • Xenical (generic version of Orlistat)
  • Ozempic (A semaglutide weight loss injection for Type 2 Diabetes)
  • Phentermine (an appetite suppressant)

These treatments differ in their active ingredients and how they work, making it essential to explore your options and consult with a healthcare professional to find the best fit for you.

Medically reviewed by:
NameMr Suhail Jamil
RoleSuperintendent Pharmacist

Gphc Number




How should Mysimba tablets be taken?

Mysimba tablets are meant to be taken orally, which means they should be swallowed whole. Avoid crushing or cutting them. If necessary, use water to aid in swallowing.

This treatment should be taken in conjunction with a well-balanced, calorie controlled/nutritional diet. No more than 30% of your calories should come from fat and your diet should generally be rich in fruit and vegetables.

You need to ensure to keep good levels of hydration by drinking 8-11 cups of liquid per day (2.7L)

Mysimba dosage

How to take mysimba?

During the first 4 weeks of Mysimba treatment, the recommended dosage changes. Initially, one tablet is taken once a day. From week 4 onwards, the maintenance dose increases to two tablets twice a day.

Starts low:

You typically begin with a low dose, often one tablet daily in the morning during the first week.

Gradual increase:

Over several weeks, the dosage is gradually increased to reach the maximum amount.

Maximum dosage:

The maximum dosage is typically four tablets per day (two in the morning, two in the evening) by week four.

Doctor's supervision: This entire process should be supervised by your doctor.

Individual variations:

The specific dosage may vary based on your weight, how you respond to the treatment, and any potential side effects.

Taken with food:

Mysimba tablets should be swallowed whole with a glass of water and taken alongside a meal.


What is the recommended Mysimba dosage per day

Mysimba dosage chart Ashcroft pharmacy uk

WeekNumber of Tablets per DayTiming
Week 11Morning
Week 221 in the morning, 1 in the evening
Week 332 in the morning, 1 in the evening
Week 4 onward4 (maximum)2 in the morning, 2 in the evening



Do not take Mysimba if:

Do not take Mysimba if:

  • You're allergic to naltrexone, bupropion, or any other ingredients
  • You have uncontrolled high blood pressure
  • You have a history of seizures or a brain tumor
  • You've recently stopped heavy drinking or sedatives
  • You have or have had bipolar disorder, an eating disorder, or are dependent on opiates
  • You're taking other medicines containing bupropion or naltrexone
  • You're on MAOIs for depression or Parkinson's, or have taken them in the last 14 days
  • You have severe liver or end-stage kidney disease.

Mysimba and Alcohol

Avoid alcohol while taking Mysimba. If you typically consume a lot of alcohol and have recently quit, or plan to quit, refrain from taking Mysimba. Talk to your doctor before starting the supplement.

Mysimba and pregnacy

Mysimba is not recommended for pregnant women or those planning to become pregnant.


  • What conditions is Mysimba suitable for?

    Mysimba is suitable for adults who are overweight or obese.

  • If you stop taking Mysimba?

    To get the full benefits of Mysimba, it may be necessary to take it for at least 16 weeks. Never stop taking Mysimba without first discussing it with your doctor.

  • What forms does Mysimba come in?

    Mysimba comes in tablet form.

  • Is Mysimba dangerous?

    Mysimba has some health risks and side effects, like most medications. However, it's safe if a doctor approves its use.

    Before starting Mysimba, your doctor should check your blood pressure and pulse, and they should be monitored regularly during treatment (weekly checks), especially if you have high blood pressure already. If your blood pressure or pulse stays high, you should stop taking Mysimba.

  • How well does Mysimba work for managing weight?

    Mysimba has shown effectiveness in reducing body weight in clinical trials. These studies involved around 4500 obese or overweight patients who received either Mysimba or a placebo alongside counseling and advice on diet and exercise.

    In three of the studies, patients on Mysimba lost around 3.7 to 5.7% of their body weight, compared to 1.3 to 1.9% with placebo.

    Additionally, a higher proportion of Mysimba-treated patients achieved significant weight loss, with 28 to 42% achieving a 5% weight loss compared to 12 to 14% with placebo.

    Furthermore, 13 to 22% of those taking Mysimba achieved at least a 10% reduction in weight, while only 5 to 6% of placebo-treated patients did so.

    In another research with more intensive counseling, the weight loss was greater overall: 8.1% with Mysimba compared to 4.9% with placebo.

    Here, 46% and 30% of Mysimba-treated patients achieved 5% and 10% weight reductions respectively, compared to 34% and 17% respectively with placebo.

    Overall, the effectiveness of Mysimba over placebo was consistent across different methods of analysis, with greater benefits observed in patients who completed 56 weeks of treatment or who had already lost at least 5% of their original body weight by 4 months into the study. Sources

  • How long does Mysimba last?

    Mysimba comes in prolonged-release tablets containing 7.2 mg naltrexone and 78 mg bupropion, available only with a prescription. The "prolonged-release" feature means the medication releases slowly over several hours.

    When you first start Mysimba, a single pack of 112 tablets lasts 5 weeks.

    Your medicine should be taken as suggested by your doctor. When you take Mysimba you will gradually increase your dose over a four-week period until you reach what is called the maintenance dose. This is the dose at which you will continue to take Mysimba.


  • When can I expect Mysimba to start showing results?

    Mysimba typically starts showing changes around week eight, based on guidance from the drug company. Studies involving over 4,500 overweight or obese patients indicate that when paired with a reduced-calorie diet and exercise,

    Mysimba can significantly impact weight by week 16. If you haven't lost at least 5% of your body weight by then, your doctor might stop your prescription.

    But don't worry, if Mysimba isn't effective for you, we offer other weight loss treatments here at Ashcroft Pharmacy UK.

  • How much does Mysimba cost in the UKt?

    The exact cost of Mysimba in the UK can vary depending on several factors, including:

    Dosage: The number of tablets prescribed per day will affect the total cost.

    Pharmacy: Different pharmacies may offer slightly different prices.

    Prescription type: There might be a difference between private prescriptions and those provided by the National Health Service (NHS).

    At Ashcroft Pharmacy, Mysimba costs around £119 for a starter pack, providing a 1 month supply of 112 tablets at £1.06 per tablet. Although effective for weight loss and approved in Europe since 2015.

  • How can i buy Mysimba weight loss pills online in the-UK?

    You can order Mysimba weight loss pills online through our UK licensed online pharmacy, Ashcroft Pharmacy. Simply complete a quick online assessment form to ensure your suitability for Mysimba. Once approved, our pharmacy team will dispatch your medication to your provided address.

  • Can i buy Mysimba over the counter?

    No, Mysimba is not available over the counter. You need a prescription from a doctor to buy it. However, you can purchase it online from Ashcroft Pharmacy uk after a quick online assessment.

  • What is the maximum daily dose of Mysimba recommended?

    The maximum recommended daily dose of Mysimba is two tablets taken twice a day.

  • How often should your doctor assess your need for continued Mysimba treatment?

    Your doctor will evaluate whether you should continue taking Mysimba after 16 weeks and each year thereafter.

  • Who should be cautious when taking Mysimba due to liver or kidney issues or age?

    Individuals with liver or kidney problems, or those older than 65, should be cautious. Their doctor may adjust the dose or monitor them more closely.

  • What is the preferred method of taking Mysimba tablets?

    Swallow your Mysimba tablets whole with food. Do not cut, chew, or crush them.

  • What should you do if you accidentally take too much Mysimba?

    If you take too many tablets, contact your doctor or nearest hospital emergency department immediately to avoid potential side effects, including seizures.

  • What should you do if you forget to take a dose of Mysimba?

    If you miss a dose, skip it and take the next dose at the usual time. Do not take a double dose to compensate for the missed one.

  • How long might it take to experience the full effects of Mysimba?

    It may take at least 16 weeks of consistent use to experience the full effects of Mysimba.

  • What are the active ingredients in Mysimba?

    The active ingredients in Mysimba are naltrexone and bupropion.

  • What should you do if you forget to take a dose of Mysimba?

    If you miss a dose, skip it and take the next dose at the usual time. Do not take a double dose to compensate for the missed one.

Side Effects

Like all medicines, Mysimba may cause some side effects, although not everybody experiences them. remember to report any unusual side effects to your doctor.

Common side effects of Mysimba, affecting more than 10% of people, include:

  • Feeling sick or vomiting
  • Constipation
  • Headaches

Less common side effects, affecting up to 10% of people, include:

  • Anxiety
  • Dizziness
  • Shakiness
  • Difficulty sleeping
  • Altered taste perception
  • Difficulty concentrating
  • Fatigue or weakness
  • Ringing in the ears
  • Fast or irregular heartbeat
  • Hot flushes
  • High blood pressure
  • Stomach pain
  • Increased sweating
  • Itching or rash
  • Hair loss
  • Irritability
  • Jitteriness

For a complete list of possible side effects, refer to the Mysimba patient information leaflet.

Seek immediate medical attention if you experience any signs of serious side effects, such as:

  • Depression or suicidal thoughts
  • Seizures
  • Skin reactions like red, itchy spots or blisters
  • Severe muscle cramps or pain
  • Skin rashes or lesions
  • Agitation, hallucinations, or other serious symptoms, especially when taking antidepressants

Mysimba may not be suitable for everyone due to potential drug interactions and preexisting health conditions. Your doctor will assess these factors before prescribing Mysimba, so be sure to provide accurate information during your consultation.

How long do mysimba side effects last?

How long do Mysimba side effects last? Generally, most side effects of Mysimba are temporary and tend to improve or disappear within a few days to a few weeks after starting the medication, especially if your body adjusts well.

Be patient: Allow your body some time to adjust to the medication.

Factors affecting duration: Several factors can influence how long side effects last, including the specific side effect, your overall health, and the dosage you're taking.

Seeking help: If side effects are severe or persist for an extended period (longer than a few weeks), it's important to consult your doctor.

They can adjust the dosage, recommend alternative medications, or suggest ways to manage the side effects.

Read the medication leaflet: The leaflet that comes with Mysimba will list potential side effects and their frequency.




Once your order has been approved by our UK medical team it will be dispatched via Royal mail. All orders are sent using a tracked and signed for service.

Royal Mail 48 | £3.49

Estimated delivery within 2-3 working days. Excludes bank holidays. Not a guaranteed service.

Free delivery on orders over £50.

RM 24 (Next working day)  | £4.99

Estimated delivery within 1 working day. Excludes bank holidays. Not a guaranteed service.

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