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Melatonin
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Thursday, 02 Jul 2026
Medication features
Melatonin for Jet Lag
Melatonin tablets help you fall asleep faster, wake up feeling refreshed, and improve overall well-being. They also support immune function and may reduce the risk of chronic diseases.
- Proven jet lag treatment
- Reduces anxiety and stress levels
- Improves memory, attention, and reaction time
Overview
NOTE: After selecting this product, you will need to complete a short assessment, so we can make sure this medication is suitable for you.
Melatonin tablets online in UK
How to Order melatonin online for UK delivery:
You can request melatonin online from UK licensed online Pharmacy. Just fill out a quick online medical questionnaire form. Our pharmacist will check your order, and if melatonin is right for you, you'll get your medication as soon as the next working day (if this option is selected).
Melatonin tablet for Jet Lag
Melatonin tablets are small pills that help you sleep better. containing the synthetic hormone melatonin, which is naturally produced in our bodies.
It is a prescription-only mediaction used to prevent and reduce jet lag symptoms or treat insomnia resulting from jet lag, such as headaches and difficulty sleeping.
Actually melatonin is a hormone produced naturally by the pineal gland in the brain. It helps to regulate your sleep-wake cycle. Normally, melatonin levels increase at night to make you feel tired and to prepare your body for sleep.
Take melatonin tablets at your destination's night time to combat jet lag and adapt to the new time zone.
In several countries, melatonin is categorized as a dietary supplement, and you can buy it from their general health food stores. But in the UK, melatonin is only available with a prescription.
You may want to buy melatonin supplements from abroad, such as melatonin 'gummies', but it's not recommended as they are not authorized for sale in the UK and therefore unregulated.
Circadian Rhythm: How Your Body’s Internal Clock Works
Our body runs on an internal clock called the circadian rhythm — a natural 24-hour cycle that controls key functions like when we feel sleepy, hormone levels, and body temperature. This rhythm is linked to the day and night pattern, or light-dark cycle, which our eyes detect and send signals about to a part of the brain called the suprachiasmatic nucleus (SCN). The SCN acts as the body’s main clock. When you travel across multiple time zones quickly, this clock struggles to sync up with the new light-dark cycle, which causes jet lag.
Jet Lag
Jet lag is a short-term sleeping problem but unpleasant, and sometimes debilitating that occurs when your body's internal clock is out of sync with the time zone you're in, normally after long flights across different time zones.
It can cause symptoms like headache, sleep disturbances, daytime weakness, insomnia, difficulty concentrating, irritability, and digestive problems and bloating.
Usually, it takes a few days for your body to adjust, but sometimes it can take a week or longer depending on the person. A general rule is that your body needs about one day to adjust for every hour of time difference, though this can vary.
If your trip is short, some people find it easier to stick to their usual sleep and meal times from home rather than changing straight away.
To reduce jet lag, it helps to shift your sleep routine before travelling, drink plenty of water, get plenty of natural sunlight when you arrive, and some use melatonin supplements to help reset their sleep cycle.
How does melatonin works for jet lag treatment?
Melatonin oral tablets help to reset the body's sleep-wake cycle to the new time zone. This can help to reduce the symptoms of jet lag and improve sleep quality.
Melatonin primarily regulates day and night cycles. Darkness triggers increased melatonin production, signaling the body to prepare for sleep.
Light reduces melatonin, signaling wakefulness. Low melatonin levels can lead to difficulty falling asleep. Taking melatonin supplements can aid in improving sleep and helping individuals fall asleep.
Is melatonin tablet safe?
Melatonin oral tablets are generally safe and well-tolerated for most people. However, they can cause side effects in some people, such as headache, dizziness, nausea, and daytime drowsiness.
It is essential to talk to your doctor before taking melatonin oral tablets, especially if you have any underlying health conditions or are taking any other medications.
Who should not use melatonin?
Most people can take it for short periods. However, some people should not take melatonin, including
- Pregnant or Breastfeeding Women
- People with autoimmune disorders, such as multiple sclerosis or rheumatoid arthritis
- People with seizure disorders
- People taking certain medications, such as blood thinners or antidepressants
How to take melatonin?
It is important to start taking melatonin on the first day of your travel and continue taking it for 2-3 days after you arrive at your destination.
To use melatonin oral tablets, take a supplement 30-60 minutes before bedtime in the destination time zone. For example, if traveling from New York to London, you would take melatonin 30-60 minutes before bedtime in London time.
- Choose a high-quality melatonin supplement.
- Start with the lowest dose available.
- Do not cut the pill.
- Take a time-released melatonin pill one to three hours before bed.
- If you cannot fall asleep within three to four hours, take another time-released melatonin pill.
- For awakenings at night that last less than one hour, take a sublingual melatonin pill.
- For awakenings at night that last more than one hour, take a time-released melatonin pill and a sublingual melatonin pill.
Good to Know
- Take melatonin at the same time each night. It helps to regulate your body's natural sleep-wake rhythm.
- Avoid taking melatonin too close to bedtime. Melatonin can make you drowsy, so it is important to give it time to work before you go to bed.
- Create a relaxing bedtime routine like taking a warm bath, reading a book, or listening to soothing music.
- Avoid caffeine and alcohol before bed. These substances can interfere with sleep.
- Ensure your bedroom is dark, quiet, and kept at a comfortable temperature.
Precautions
Melatonin can interact with specific medications, including blood thinners and antidepressants. Talk to your doctor before taking melatonin, especially if you have any underlying health conditions or are taking any other medications.
Takeaway
Melatonin oral tablets are a safe and effective way to improve sleep quality and reduce the symptoms of jet lag. If you are struggling with sleep problems, talk to your doctor about whether melatonin oral tablets are right for you.
Directions
Reducing Jet Lag Without Medication
- Before you travel, adjust your bedtime closer to your destination's bedtime and ensure you're well-rested.
- Stay calm and relaxed during your journey.
- Stay hydrated by drinking plenty of water, especially during the flight.
- Avoid alcohol.
- Move around on the plane when possible.
- Set your watch to the destination time at the beginning of the flight.
- Sleep during the journey according to the destination's nighttime hours.
- Upon arrival, try to sleep and eat according to the destination's times.
- Keep your sleeping environment dark at night, even if you're awake.
- Avoid daytime naps.
- Spend time outdoors, particularly in the afternoon when traveling west and in the morning when traveling east. Natural light helps with adjustment, or you can use a SAD (Seasonal Affective Disorder) light at these times.
Dosage
Melatonin dosage
The recommended dose of melatonin for jet lag treatment is 0.5-5 milligrams. Beginning with a minimal dosage and adjusting as required is the recommended approach.
Start taking Melatonin as soon as possible after your symptoms begin. Swallow the tablet whole with a glass of water, with or without food, three times a day for 5 days.
FAQ
What is Melatonin?
Melatonin is a sleep hormone that is produced naturally in the body to regulate your sleep cycle.
How long does melatonin take to start working?
Melatonin takes effect within 20-40 minutes (some up to 1-2 hours). So take it 30-60 minutes before bedtime.
Where can I buy Melatonin online in the UK?
You can order Melatonin from UK-registered Ashcroft Pharmacy at the lowest price only £14.99, by completing a short online assessment. This helps ensure the medication is suitable for you.
How long will I take melatonin to treat insomnia?
You'll usually take melatonin for 1-4 weeks to treat insomnia, up to 13 weeks in some cases. If it doesn't work after 13 weeks, try lifestyle changes or see a doctor again. For some types of insomnia, it can be a long-term treatment.
How to take melatonin for jet lag?
Dosage: The usual dose is 1 tablets (3mg) 30-60 mins. before bedtime. Your doctor may recommend 2 tablets (6mg) based on your needs.
Timing: Take melatonin when you arrive at your destination at your normal bedtime. However, avoid taking it before 8pm or after 4am.
Duration: You can use melatonin for up to 5 nights in a row.How does melatonin work for jet lag?
Melatonin helps reset your body's clock to the new time zone, easing jet lag symptoms like fatigue and insomnia. Take 1-2 tablets at bedtime, between 8pm and 4am, for up to 5 nights. Talk to your doctor first.
Will you sleepwalk with Melatonin?
Taking Melatonin is not linked to sleepwalking.
If you have a history of sleepwalking or are concerned about the possibility, it's best to consult your doctor before taking melatonin.
Resources that you may find helpful:
National Sleep Foundation: https://www.sleepfoundation.org/parasomnias/sleepwalking
Mayo Clinic: https://www.mayoclinic.org/diseases-conditions/sleepwalking/symptoms-causes/syc-20353506
American Academy of Sleep Medicine: https://aasm.org/Can I get addicted to melatonin?
No, you won't get addicted to melatonin if taken as directed for short-term sleep issues. However, if you've been using it for a long time, consult your doctor before stopping. They can help you safely stop taking melatonin.
Can I buy melatonin supplements at a health food shop?
Unfortunately, in the UK, you cannot buy melatonin supplements at a health food shop. Melatonin is a prescription-only medicine in the UK, and it's not available for purchase over the counter.
Will it affect my contraception or HRT?
Melatonin won't affect your birth control. It is safe to take with hormonal contraceptives like the pill and emergency contraception.
However, the combined pill and hormone replacement therapy (HRT) can boost the amount of melatonin in your body. This is usually safe and harmless. Talk to your doctor if you have any concerns.
Can I drive or ride a bike while taking Melatonin?
Don't drive or ride a bike if melatonin makes you sleepy, dizzy, or affects your concentration. This applies to both starting and continuing treatment.
Wait until any side effects disappear before driving or operating machinery. You may also want to consult a doctor or pharmacist if you're unsure.
Remember, driving under the influence can be dangerous and illegal. Always prioritize safety and make responsible decisions.
Learn More> GOV.UK has more information on the law on drugs and driving.
Can I drink alcohol while taking melatonin?
Don't Drink Alcohol with Melatonin: It's Dangerous! Both make you sleepy, leading to overly deep sleep. You may struggle to wake up or breathe properly. Avoid alcohol completely while taking melatonin.
Is there any food or drink I need to avoid?
Yes, you need to avoid drinks containing caffeine (including tea, coffee, cola, and energy drinks) and alcohol while taking melatonin. These substances can interfere with melatonin's effectiveness in promoting sleep.
Side Effects
Side effects of melatonin tablets include:
Melatonin oral tablets are generally safe and well-tolerated for most people. However, they can cause side effects in some people, such as headache, dizziness, nausea, anxiety, and daytime drowsiness.
o see all possible side effects of Melatonin tablets, please read the patient leaflet carefully.
Information
Patient Information Leaflet (from EMC): Melatonin
Delivery
Once your order has been approved by our UK medical team it will be dispatched via Royal mail. All orders are sent using a tracked and signed for service.
Royal Mail 48 (2-5 days) | £2.49
Estimated delivery within 2-3 working days. Excludes bank holidays. Not a guaranteed service.
Free standard delivery on orders over £45.
Royal Mail 24 (1-2 days) | £2.95
Estimated delivery within 1 working day. Excludes bank holidays. Not a guaranteed service.
Royal Mail Special Delivery Guaranteed by 1pm | £6.99
Order by the 2:00 PM weekday cut-off time for guaranteed delivery by 1:00 PM the next business day.
Orders placed after the cut-off on Friday will be delivered on Tuesday.
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Written and reviewed by our qualified team

Authored by:
Mr Suhail Jamil
Superintendent Pharmacist
GPhC Number: 2069518
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