Differin 0.1% Cream/Gel | Treat Acne

Buy Differin Cream Online | Ashcroft Pharmacy UK
  • Buy Differin Cream Online | Ashcroft Pharmacy UK
  • Buy Differin Gel Online | Ashcroft Pharmacy UK

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Differin 0.1% Cream/Gel | Treat Acne

Fastest delivery:
Tuesday, 18 Jun 2024
  • Medication features

    Differin is a prescription-only skin treatment for acne. Works by fixing root cause of acne. It's clinically proven to clear acne, leaving your skin looking clear and oil-free.

    • For acne prone sensitive skin
    • Reduces visible redness and irritation of the skin
    • Prevents new acne from forming
    • Clears breakouts deep in pores
    • Restores skin texture and tone
    • Complete a 3-month course for significant results
    • Contains the active ingredient Adapalene (retinoid)
    • We stock 2 different variants cream/Gel
    • Differin Cream Leaflet
    • Differin Gel Leaflet
    • Price Much Guarantee

    Registered UK Pharmacy Number 1039428

Order in the next for Tuesday delivery

Fastest delivery: Tuesday, 18 Jun 2024


NOTE: After selecting this product, you will need to complete a short assessment, so we can make sure this medication is suitable for you.

Buy Differin - Adapalene Acne Treatment

Differin cream or gel contains the active ingredient, adapalene, which is used to treat mild to moderate acne. Adapalene is classed as a third generation retinoid (a form of vitamin-A).

It is highly effective in addressing issues related to excessive oil production, inflammation, and abnormal skin cell growth that contribute to acne.

Adapalene is known for its relatively low side effects compared to some other retinoids, making it a popular choice in acne treatment.

How does Differin work?

Differin cream/Gel's active ingredient, adapalene, treats acne by reducing inflammation and preventing the formation of blackheads, whiteheads, pustules, and cysts.

It limits the growth of skin cells that can clog pores, regulates oil production, and boosts natural skin cell turnover. This helps clear existing outbreaks and prevent further acne occurrences.

Application and Use:

  • Applied topically to the face, chest, or back for prescription-strength acne treatment.
  • Quick absorption due to the gel form, ideal for oily skin.
  • Nighttime application recommended for optimal effectiveness.
  • Usage involves cleansing, patting dry, applying a thin layer, and subsequent moisturization.
  • Sunscreen usage is advised due to increased skin sensitivity.

Using other products with Differin:

You can use other acne products containing benzoyl peroxide, erythromycin, or clindamycin along with Differin. Apply them in the morning and Differin at night.

You can use other cosmetics, but ensure they don't cause blackheads or dry out the skin. Inform your doctor or pharmacist about any other medicines you are taking or have recently taken.

Results and Effectiveness:

  • Results may take 4-6 weeks, with a doctor's review recommended after 12 weeks.
  • Effectiveness varies among individuals.
  • Alternatives should be considered if no improvement is observed after six weeks.

❌ DO NOT use Differin if:

  • You are pregnant.
  • You are planning a pregnancy.
  • You are allergic to adapalene or any of the other ingredients in this medicine.
NameMr Suhail Jamil
RoleSuperintendent Pharmacist
GPhc Number2069518


Patient Information Leaflet (from EMC): https://www.medicines.org.uk/emc/product/920/pil





Who should NOT use Differin

  • Not suitable for pregnant women, those planning pregnancy, or individuals allergic to any ingredients.
  • Caution during breastfeeding; avoid chest application.
  • Avoid on broken skin, cuts, or sores.


How to Apply Differin Gel?

Wash and dry the acne affected areas with warm water and apply a thin layer of Differin cream/gel to the affected areas once daily at bedtime.

Ensure that it is applied to the whole area and not just individual spots. Rub the cream/gel in with fingertips and use sparing amounts.

Excess use of Differin may irritate the skin further. Do not apply Differin cream/gel near the eyes, lips, nostrils or on any broken skin. Wash your hands thoroughly before and after use.

If you experience dry and irritated skin at the start of Differin treatment, you may want to try using Differin every other day and work up to daily treatment.

Sunlight and UV light should be avoided with use of Differin, this includes sunbeds.


⚠️ Warnings and Precautions for Using Differin:

  • Do not apply this medicine on areas with cuts, scrapes, sunburnt skin, or if you have eczema.

  • Avoid contact with eyes, mouth, or angles of the nose, and sensitive areas of your body. If accidental contact occurs, wash with warm water immediately.

  • Stay away from strong sunlight and artificial UV light. Use sunscreen and wear protective clothing over the treated area.

  • If you experience sensitivity or irritation, discontinue use and inform your doctor. You may need to use the cream less often or stop until symptoms subside.

  • If you're unsure about anything, talk to your doctor or pharmacist.

⚠️ Disposal and Storage:

  • Dispose of at a pharmacy; do not throw it in the bin.
  • Store in the original tube below 25°C; do not freeze.


  • What are the benefits of Differin (Adapalene) gel or cream?

    • Non-comedogenic - does not clog pores
    • Actively clears and prevents acne
    • Restores skin tone and texture
    • Fragrance-free
  • How long does it take to start seeing results while using Differin?

    To get the best results, differin should be applied consistently and continually. Results can be observed between 8 to 12 weeks if used correctly.

  • Will it be more effective if I use an excessive quantity of Differin?

    If you use too much Differin on your skin, it won't clear acne faster, but it may cause irritation, redness, and some peeling or discomfort. If you accidentally swallow any, seek medical advice—it's a rare occurrence.

  • About Acne

    Acne is a common and often distressing condition, but the good news is that it's usually treatable.

    Many individuals experience acne during their youth, typically lasting around 4-5 years. However, it can persist into adulthood and affect areas like the face, chest, and back. Hormonal changes, especially during puberty, often trigger acne.

    Excessive oil production and the combination of sebum and shed skin cells can block pores, leading to the development of blackheads and whiteheads. The presence of acne bacteria in blocked pores can result in inflammation, pustules, and cysts.

    For severe acne with pustules, nodules, and scarring, a face-to-face assessment with a doctor is essential, and a specialist referral may be considered.

    It's crucial to note that acne differs from rosacea, which may appear similar but lacks blackheads.

    Fortunately, untreated acne typically resolves without scarring. Treatment options range from non-prescription skin preparations available at pharmacies to prescription topical preparations and tablets, including antibiotics.

    If you're dealing with acne, consult with a healthcare professional to determine the most suitable treatment for your specific situation.

  • Can I skip a day of Differin Cream/gel?

    Yes, you can skip a day of Differin Gel. However, it's generally recommended to use it daily for optimal effectiveness in treating acne.

    Expert Recommendation is: Make Differin® Cream/ Gel a part of your daily skincare routine and use it as directed to keep the problems away.

  • Are there any side effects?

    Differin® Gel is well-tolerated, especially when compared to other retinoid acne products without adapalene. Some common side effects may include dryness, redness, irritation, and a burning or stinging sensation.

    These effects typically peak around 2 to 4 weeks before getting better. It's important to note that not everyone experiences these side effects, and in clinical studies, they were generally mild.

  • Why use a moisturizer with Differin® Gel, especially at the start?

    Using a moisturizer with Differin® Gel, especially at the start, helps prevent dryness that may occur during the initial stages of using the gel.

    This is important because Differin® Gel, while effective for treating acne, can sometimes lead to dryness or irritation.

    The moisturizer complements the treatment by hydrating the skin, making the overall experience more comfortable and supporting healthier skin during the adjustment period.

  • How can I achieve the best results from Differin?

    To achieve the best results from Differin, consider the following tips:

    1. Consistent Use: Apply Differin as directed by your healthcare provider. Consistency is key for optimal effectiveness.

    2. Start Slow: Begin with a smaller amount to allow your skin to acclimate, especially if you're new to retinoid products.

    3. Cleanse Before Application: Ensure your face is clean before applying Differin to maximize absorption.

    4. Apply to Dry Skin: Apply Differin to completely dry skin to minimize potential irritation.

    5. Use a Moisturizer: Incorporate a non-comedogenic/gentle moisturizer to prevent dryness and irritation.

    6. Sun Protection: Always use sunscreen during the day as Differin can increase sensitivity to sunlight.

    7. Patience is Key: Results may take weeks to months, so be patient and continue use unless advised otherwise by your healthcare provider.

    8. Avoid Harsh Products: Avoid strong skincare products, as they can worsen irritation when used with Differin.

    Consult Your Healthcare Provider: If you have concerns or experience persistent side effects, consult your healthcare provider for guidance.

  • How do Differin® gel/cream work together for better skincare?

    Differin® gel/cream works for better skincare through a three-way approach:

    • Adapalene Gel/Cream: The active ingredient clears and prevents acne.
    • Moisturizer: Prevents dryness, especially during the initial stages of using Differin® Gel/Cream.
    • Cleanser: Washes away impurities without causing irritation.

    Together, these elements provide comprehensive care, addressing various aspects of skincare for improved results.

  • Why I need to use an acne gel, cleanser, and moisturizer all together?

    Your skincare routine is unique, but your current products might not be doing enough. Differin® products complement each other, enhancing your routine.

    Differin® adapalene gel fights acne, the moisturizer prevents dryness caused by Differin® Gel, especially in the early stages, and the cleanser removes impurities without irritation. This three-way approach provides comprehensive care from every angle.

  • Is it necessary to continue using Differin® Gel after my acne has cleared?

    For optimal results, keep using Differin® Gel even after your skin improves to prevent future breakouts. Ongoing use will help maintain clear skin, prevent blackheads and clogged pores, and restore a smoother texture and tone.

  • Are there any restrictions or activities I should avoid after applying Differin® Gel?

    Avoid using Differin® Gel with products containing alpha hydroxy, salicylic, or glycolic acids, as it can cause irritation. Using multiple acne products together may also irritate your skin. Skip waxing where you've applied the product, and use sunscreen when going outside to protect your skin.

  • Who can use Differin® Gel?

    Differin® Gel is suitable for individuals aged 12 and older with mild-to-moderate acne. If you have severe acne, consult your doctor or visit acne.com for additional information.

  • Is it okay for pregnant women to use Differin® Gel?

    While Differin® Gel is a safe and effective treatment. However, as with any medication, it's advisable to consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Most experts recommend discontinuing this treatment during pregnancy.

Side Effects

Side effects include:

  • itching
  • dryness
  • a warm/stinging sensation
  • scaling
  • redness or worsening of acne

However, this is usually just for the first couple of weeks of use and symptoms will start to settle with continued use. If any side effects get worse, please consult your doctor.


Differin 0.1% Cream/Gel Specification

Medicin TypeTopical retinoid (POM)
Class of medicationsretinoids
Works byaffecting the growth of cells and decreasing swelling and inflammation
Effective withinas little as in 2 weeks
Can be usedfor acne on face, chest, or back with blackheads and pimples.
International NameAdapalene
Active ingredientAdapalene
Pack size1 tube 45 g
Retinol strength0.1%
ManufacturerGalderma (UK) Ltd
Lowest Price£23.99


Once your order has been approved by our UK medical team it will be dispatched via Royal mail. All orders are sent using a tracked and signed for service.

Royal Mail 48 (2-5 days) | £3.49

Estimated delivery within 2-3 working days. Excludes bank holidays. Not a guaranteed service.

Free delivery on orders over £50.

Royal Mail 24 (Next working day) | £4.99

Estimated delivery within 1 working day. Excludes bank holidays. Not a guaranteed service.

Royal Mail Special Delivery Guaranteed by 1pm | £9.95

Order by the 2:00 PM weekday cut-off time for guaranteed delivery by 1:00 PM the next business day.

Orders placed after the cut-off on Friday will be delivered on Tuesday.

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