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Omeprazole
In Stock
Tuesday, 30 Jun 2026
Medication features
Omeprazole gastro-resistant capsules are a proton pump inhibitor (PPI) that reduces excessive stomach acid production, providing relief for indigestion and heartburn caused by acid reflux. Typically prescribed for short-term use (4-5 days), it is taken once or twice daily as needed.
- Treats GORD and peptic ulcers
- Controls excessive stomach acid production
- Browse Alternative Acid Reflux Treatments
Overview
NOTE: After selecting this product, you will need to complete a short assessment, so we can make sure this medication is suitable for you.
Omeprazole Overview
You can order Omeprazole gastro-resistant capsules (20mg or 10mg) online from Ashcroft Pharmacy after a quick online assessment.
Once you have completed your assessment and checkout, our prescribing pharmacists will review your order to check that this treatment is right for you. Once approved, our pharmacy team will quickly dispatch your medication.What is Omeprazole used for?
Highlights:
• Relieves heartburn and acid reflux
• Prevents ulcers from recurring
• Treats ulcers
• Protects the oesophagus from damageOmeprazole is a proton pump inhibitor (PPI) used to treat certain stomach and oesophagus conditions, including acid reflux and ulcers.
It works by reducing the amount of acid produced in the stomach. This can help relieve symptoms such as heartburn, acid reflux, indigestion, difficulty swallowing, and cough. Omeprazole can also be used to treat and prevent ulcers.
Who should not take Omeprazole?
Most people can take Omeprazole. However, tell your doctor or pharmacist before taking it if you:
• Have ever had an allergic reaction to Omeprazole or any other medicine
• Have liver problems
• Are due to have an endoscopyOmeprazole capsules for acid reflux
The medical name for long-term acid reflux is gastro-oesophageal reflux disease, also known as GORD. Acid reflux, often referred to as heartburn, occurs when stomach acid moves up into the gullet (oesophagus) and throat.
This can cause a burning sensation in the chest and an unpleasant taste in the mouth. Each Omeprazole dose can help control acid production for up to 24 hours.
Shop our full range of acid reflux management treatments to see what other products are available.
Omeprazole for indigestion
Indigestion, also known as dyspepsia, causes discomfort or pain in the upper stomach and may make you feel bloated or nauseous. Indigestion can also trigger acid reflux symptoms.
Omeprazole 10mg or 20mg can be used to treat these symptoms effectively, and is particularly helpful for relieving heartburn and indigestion.
Lesser-known benefits of Omeprazole
• Helps with silent reflux (LPR) by reducing throat irritation, chronic cough, and hoarseness
• Helps prevent NSAID-induced ulcers by protecting the stomach lining in long-term NSAID users
• Reduces aspiration pneumonia risk by lowering acid exposure in patients prone to aspiration
• Improves absorption of some medicines, increasing their effectiveness
• Helps manage Zollinger–Ellison syndrome by controlling excessive acid production
• Supports Helicobacter pylori treatment as part of ulcer eradication therapy
• Used in hospitals to help prevent gastrointestinal bleeding in critically ill patientsHow does Omeprazole work?
Omeprazole 10mg and 20mg works as a proton pump inhibitor. It reduces stomach acid by blocking the proton pump in the stomach lining, which is responsible for acid production.
When this pump is blocked, the stomach produces less acid, helping to relieve symptoms such as acid reflux, excess stomach acid, and certain types of ulcers.
How long does Omeprazole take to start working?
Omeprazole may start relieving symptoms within the first few doses, although this can vary between individuals. For some people, it may take up to four weeks to experience the full effect.
If your symptoms do not improve after five days of treatment, you should speak to your GP or another healthcare professional.
How to take Omeprazole tablets/capsules
Omeprazole is usually taken once a day, ideally before a meal. It can be taken with or without food, but taking it on an empty stomach may help it absorb more quickly.
Swallow the capsule whole with a glass of water. Do not crush or chew the capsule.
A 10mg dose is commonly taken once daily in the morning. In some cases, a twice-daily dose may be prescribed. If so, doses should be taken 12 hours apart, usually morning and evening.
If you forget to take a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue as normal. Do not take a double dose.
Is Omeprazole safe for pregnant women?
In order to address whether a pregnant woman can take Omeprazole, the links between Omeprazole and pregnancy have been widely studied, concluding that Omeprazole is safe to use during pregnancy.
Current medical evidence suggests that Omeprazole does not harm the developing baby. It is typically the first-choice medication for pregnant women when lifestyle changes and antacids have failed to manage severe reflux.
We recommend a brief consultation with your GP before use of Omeprazole tablets during pregnancy to ensure the dosage is tailored to your specific needs.Is it safe to take Omeprazole while breastfeeding?
Official NHS guidance states that you can “usually take Omeprazole while breastfeeding, but check with a pharmacist or doctor first”.
The NHS Special Pharmacy Service provides the following advice for breastfeeding full-term and healthy infants:
“Any PPI can be used during breastfeeding, however Omeprazole and pantoprazole are the PPIs of choice as they are excreted into breast milk in very small amounts and have evidence to support their use. Any PPI that passes into breast milk is likely to be degraded in the infant’s gastrointestinal tract.”
If you’re unsure, we recommend you talk to your GP before using this medication.
How long should I take Omeprazole?
For short-term acid reflux symptoms, Omeprazole is typically taken for around four to five days without medical advice.
If symptoms continue beyond this period, you should speak to your GP. Ongoing symptoms may indicate an underlying condition that needs further investigation.
What are the alternatives to Omeprazole?
The most suitable alternative depends on your symptoms and medical history. Other proton pump inhibitors, such as lansoprazole, may be appropriate in some cases.
Lifestyle changes, including avoiding trigger foods, eating smaller meals, and maintaining a healthy weight, may also help reduce acid reflux. However, these changes alone may not be sufficient for people with more severe symptoms.
Can Omeprazole be taken with other heartburn medicines?
Antacids such as Gaviscon can be taken with Omeprazole, but they should be taken at least two hours after your Omeprazole dose.
If you find that you need to use antacids regularly while taking Omeprazole, speak to your doctor or pharmacist. Other heartburn treatments should not be taken alongside Omeprazole unless advised by a healthcare professional.
Resources:
The best time to take Omeprazole
In order to achieve the best results and a reduction in gastric acid, the best time to take Omeprazole is critically important. Omeprazole capsules are a Proton Pump Inhibitor (PPI), which reduces the amount of acid in your stomach.
Follow the 30-minute rule
The best time to take Omeprazole is 30 to 60 minutes before your first meal. This allows the Omeprazole tablets time to circulate in your system before the acid pumps are activated by food.
Maintain consistency
While Omeprazole gastro-resistant capsules can lead to relief being felt within hours, they can take 2 to 3 days of use to reach full effectiveness.
How to administer Omeprazole capsules
Be sure to swallow the Omeprazole tablet whole with water. Do not crush or chew the tablet, as this destroys the enteric coating designed to protect the medicine from stomach acid.Choosing your treatment: Omeprazole vs. Lansoprazole and alternatives
Omeprazole:
Primary use: The prevention of frequent heartburn
Duration: Up to 24 hours of acid suppression
Mechanism: Stops acid production at the source within the body
Best For: Chronic acid reflux, GERD, and Ulcers
Lansoprazole:
Primary use: Immediate relief of symptoms of heartburn
Duration: 2–4 hours of relief from heartburn
Mechanism: Neutralises existing stomach acid
Best For: Occasional indigestion after meals
If seeking an alternative to Omeprazole capsules, the most suitable option depends on your symptoms and medical history. Other proton pump inhibitors, such as lansoprazole, may be appropriate in some cases. When comparing Omeprazole vs Lansoprazole, the two medications have largely the same purpose; Lansoprazole is generally considered to act faster and be more potent.
PPI medication should never be taken alongside other PPI medication. For example, Omeprazole should never be taken concurrently with Lansoprazole, regardless of dosage.
Omeprazole is generally considered to be the preferred PPI for consumption during pregnancy.
Directions
Dosage
Take 1 or 2 capsules once or twice a day with water. The pill should not be broken or chewed; it should be swallowed whole. It should be consumed preferably in the morning at the same time every day.
Our Omeprazole capsules are available in 2 strengths:
- Omeprazole 10 mg
- Omeprazole 20 mg
Patients with acid reflux have shown significant improvement when using Omeprazole. The effects of Omeprazole were more beneficial in those taking 20mg once daily compared to those taking 10mg once daily.
Warnings
Omeprazole and other medications
Omeprazole can interact with other medicines, so it is important to speak to your GP before starting treatment. Make sure they are aware of all medicines you are taking, including over-the-counter treatments, supplements, and herbal remedies such as:
- Vitamin K blockers (e.g. warfarin)
- Clopidogrel
- Digoxin
- Epilepsy medication (e.g. diazepam, phenytoin)
- Antifungal medicines (e.g. ketoconazole, voriconazole, itraconazole)
- HIV medicines (e.g. atazanavir, saquinavir)
- Methotrexate
- Rifampicin
- St John's wort
- Corticosteroids
- Tacrolimus
If you experience any of the following symptoms while taking Omeprazole, consult your GP promptly:
- Difficulty swallowing
- Sudden weight loss
- Blood in vomit or stools
- Liver issues
These symptoms could indicate potential complications or side effects requiring medical attention.
FAQ
What is the difference between Omeprazole and Losec?
Losec is the branded version of Omeprazole, while Omeprazole is the generic version. Both medicines work in the same way and contain the same amount of the active ingredient, Omeprazole. Losec is typically more expensive because it’s the branded one.
Is Omeprazole safe?
Omeprazole is generally used as a short-term treatment for conditions such as ulcers, oesophagitis, and heartburn. Omeprazole sodium bicarbonate and Omeprazole magnesium are available as delayed-release tablets or capsules.
Some medicines are not suitable for people with certain conditions, and in some cases extra care is needed when using them. For this reason, you should tell your doctor or pharmacist before starting Omeprazole.
When taken as prescribed, Omeprazole 10mg or 20mg is considered generally safe and effective. If symptoms continue after two weeks of treatment, you should consult a doctor for further advice and assessment.
Proton pump inhibitors such as Omeprazole have been associated with an increased risk of kidney disease, pneumonia, and certain bacterial infections, particularly with long-term use.Is Omeprazole right for me?
Omeprazole has been linked to kidney-related side effects. You should inform your doctor if you are urinating less than usual or notice blood in your urine. Diarrhoea may be a sign of a new infection.
If you develop watery or bloody diarrhoea, contact your doctor promptly. Omeprazole should not be used for the immediate relief of heartburn symptoms.
Omeprazole may also trigger new or worsening lupus symptoms. Tell your doctor if you develop joint pain or a skin rash that worsens in sunlight, particularly on your face or arms.Can I take Omeprazole with alcohol?
Yes, it is generally safe to drink alcohol while taking Omeprazole, as alcohol does not directly affect the medicine.
However, alcohol can worsen acid reflux symptoms. If Omeprazole makes you feel dizzy, alcohol may increase this effect and should be avoided.What is the best time to take Omeprazole?
Omeprazole is usually taken once a day, first thing in the morning. It can be taken with or without food.
If prescribed twice daily, take one dose in the morning and one dose in the evening.Can Omeprazole cause weight gain?
Weight gain is a rare side effect of Omeprazole. Some people may gain a small amount of weight during long-term use, often because relief from acid reflux allows them to eat more comfortably, rather than due to an increase in appetite caused by the medicine itself.
Can I Buy Omeprazole over the counter in the UK?
Yes, Omeprazole 10mg tablets are available over the counter from pharmacies and supermarkets. Capsules are prescription-only.
Over-the-counter Omeprazole is suitable for adults for a maximum of 14 days. Do not take Omeprazole for more than 14 days without speaking to a doctor.Is Omeprazole better than Gaviscon?
Both Omeprazole and Gaviscon are generally well tolerated. Gaviscon can provide comparable 24-hour relief for moderate, episodic heartburn and may be a suitable alternative to Omeprazole for managing moderate GERD in primary care.
Can I take omeprazole every day?
You should not take over-the-counter Omeprazole for longer than 14 days without medical advice.
Prescription Omeprazole is often prescribed for 4 to 8 weeks, depending on the condition being treated. In some cases, longer treatment may be required, but prolonged use can increase the risk of side effects and should be monitored by your GP.Can I take Omeprazole at night?
Taking Omeprazole at night may be recommended for people with severe acid reflux or night time symptoms. If taking it in the evening, it is generally advised to take the dose 1 to 2 hours before bedtime.
Which proton pump inhibitor is best?
Esomeprazole 40mg has been shown to provide stronger acid control than some other proton pump inhibitors, including:
• Lansoprazole 30mg
• Omeprazole 20mg
• Pantoprazole 40mg
• Rabeprazole 20mg
The most suitable PPI varies between individuals, so a healthcare professional should be consulted for personalised advice.Is long term Omeprazole safe?
Long-term use of Omeprazole may carry some risks, including kidney problems and bone fractures, alongside more common side effects such as headaches and stomach pain.
For this reason, Omeprazole should be used under medical supervision and for the shortest effective duration. Regular reviews with your GP are important when long-term treatment is needed.Does Omeprazole affect the kidneys?
Omeprazole is used to reduce stomach acid, but it may increase the risk of kidney-related problems. It has been associated with acute kidney injury and may worsen existing chronic kidney disease in some individuals.
Does omeprazole slow digestion?
Omeprazole and other PPIs can delay gastric emptying, meaning digestion may slow down slightly. While these medicines are widely used and generally safe, you should speak to a healthcare professional if you notice digestive changes that concern you.
Can omeprazole cause fatty liver?
Some studies have found an association between proton pump inhibitor use and an increased risk of fatty liver disease, particularly with long-term use.
Why is omeprazole better in the morning?
Taking Omeprazole in the morning allows it to be absorbed more effectively, particularly when taken on an empty stomach.
Why take medicine 30 minutes after eating?
Taking some medicines 30 minutes after food can help reduce the risk of side effects such as stomach irritation, indigestion, inflammation, or ulcers.
Can i take Omeprazole with milk?
It is not recommended to take Omeprazole with milk, fizzy drinks, or fruit juices, as these can interfere with absorption. Water is the best option.
Can you take omeprazole with antibiotics?
Yes, Omeprazole can be taken with antibiotics. In some cases, it is sometimes used alongside antibiotics as part of a combination treatment.
What are the different forms of Omeprazole available?
Omeprazole is available as capsules, tablets, and oral liquid. It can be purchased over the counter or prescribed by a doctor. The dose and form used will depend on the condition being treated and individual's response to the medicine.
Compare
Comparison Table of Omeprazole (Losec) and Ranitidine (Zantac) as treatments:
| Aspect | Omeprazole / Losec | Ranitidine / Zantac |
| Ingredient | Omeprazole 10 or 20mg | Ranitidine 150 or 300mg |
| Mechanism | PPI - reduces acid in stomach | H2 Blocker - reduces acid in stomach |
| Side Effects | Diarrhea, headache, nausea, vomiting | Diarrhea, headache, nausea, vomiting |
| Dosage | Taken ONCE or TWICE daily as required | Taken ONCE or TWICE daily as required |
| Brand | Prilosec and Losec | Zantac |
Side Effects
Some common side effects of Omeprazole are as follows:
More than 1 in 100 persons experience these common Omeprazole adverse effects. You can take steps to assist yourself in dealing with them.
- nausea
- diarrhoea
- vomiting
- stomachache
- constipation
- farting (Flatulence)
Serious side effects of Omeprazole are as follows:
Less than 1 in 1,000 persons experience serious adverse effects.
- Your pee turns darker, your complexion turns yellow (although this may be less noticeable if you have brown or black skin), and you feel more exhausted. All might be symptoms of liver issues.
- Joint discomfort and a red skin rash, particularly on exposed areas of the body like the arms, cheeks, and nose, may be symptoms of a rare illness called subacute cutaneous lupus erythematosus. This might still occur even if you've taken Omeprazole for a while.
- Diarrhoea that is severe or prolonged may indicate an irritated bowel.
Visit a doctor straight away if any of these symptoms persist.
Precautions:
Tell your doctor or pharmacist before using Omeprazole if you have any allergies to it, any comparable medications (such as esomeprazole, lansoprazole, or pantoprazole), or any other medicines.
Inactive chemicals in this product have the potential to trigger allergic reactions or other issues. To learn more, speak with your pharmacist.
Inform your doctor or pharmacist about your current medications, especially those for liver disease and lupus.
Some symptoms could be warning indications for a more severe ailment. Get medical attention immediately if you experience any of the following symptoms:
- Heartburn with fainting, sweating, or dizziness; chest, jaw, arm, or shoulder discomfort (particularly if it is accompanied by shortness of breath or extreme sweat); or unexplained weight loss.
Additionally, before using this medication on your own, seek immediate medical attention if you experience any of the following symptoms of a severe condition:
- Difficulty or pain swallowing, bloody or black stools, bloody or coffee-ground-looking vomit, heartburn that has persisted for more than three months, frequent chest pain, frequent wheezing (especially with heartburn), nausea/vomiting, or stomach pain.
Inform your surgeon or dentist of all the products you use before surgery (including prescription drugs, nonprescription drugs, and herbal products).
Information
Omeprazole Patient Information Leaflet
Omeprazole 10 mg & 20 mg Capsules full specification
| Product name | Omeprazole |
| Brand name | Prilosec and Losec |
| Madicine Type | Proton pump inhibitor (PPI) |
| Dose | Taken ONCE or TWICE daily as precribed |
| Mechanism of Action | Omeprazole is a proton pump inhibitor (PPI) that blocks hydrogen, a key element for stomach acid production. |
| Success ratio | Over 93% |
| Effective results | within hrs. and full effects seen in 2 to 3 days |
| Suitable for | Adults who suffering from acid reflux and heartburn |
| Pack Size | 28 capsules |
| Common Side Effects | headaches, diarrhea, and stomach pain |
| Avaiable Strength | 10mg, 20mg |
| Omeprazole lowest Price in UK | From£1.99 |
Delivery
Once your order has been approved by our UK medical team it will be dispatched via Royal mail. All orders are sent using a tracked and signed for service.
Royal Mail 48 (2-5 days) | £2.49
Estimated delivery within 2-3 working days. Excludes bank holidays. Not a guaranteed service.
Free standard delivery on orders over £45.
Royal Mail 24 (1-2 days) | £2.95
Estimated delivery within 1 working day. Excludes bank holidays. Not a guaranteed service.
Royal Mail Special Delivery Guaranteed by 1pm | £6.99
Order by the 2:00 PM weekday cut-off time for guaranteed delivery by 1:00 PM the next business day.
Orders placed after the cut-off on Friday will be delivered on Tuesday.
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Authored by:
Mr Suhail Jamil
Superintendent Pharmacist
GPhC Number: 2069518
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