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Naproxen Tablets (250mg & 500mg)
In Stock
Thursday, 02 Jul 2026
Medication features
Naproxen tablets are versatile prescription painkillers that reduce pain, swelling, and inflammation. It's effective for headaches, arthritis, menstrual cramps, sprains, and more. Providing long-lasting relief for up to 12 hours, Naproxen for pain relief is common. This drug is used for a few days for short-term pain or longer for chronic conditions, as advised by a doctor.
- Anti-inflammatory Naproxen tablets
- Relief from gout, period pain, and muscle/joint pain
- Prescription Naproxen painkillers. Alternatives include ibuprofen, diclofenac and aspirin
Overview
NOTE: After selecting this product, you will need to complete a short assessment, so we can make sure this medication is suitable for you.
Naproxen Tablets 250mg & 500mg
Taking a Proton Pump Inhibitor (PPI) with Naproxen tablets and other NSAIDs helps protect your stomach from potential damage. NSAIDs can irritate the stomach lining, leading to ulcers or bleeding. A PPI reduces stomach acid, lowering the risk of these issues, especially with long-term NSAID use. We recommend you add Lansoprazole 15mg to your order.
Naproxen oral tablet is a generic medication used to treat pain and inflammation caused by conditions like arthritis or tendonitis. It is also marketed under brand names like Anaprox DS, Naprelan, and Naprosyn. Through our UK-registered online prescribing service, you can request prescription Naproxen tablets 250mg or Naproxen tablets 500mg after completing a quick medical assessment.
What is the purpose of Naproxen for Pain Relief?
Naproxen is a non-steroidal anti-inflammatory medication that reduces pain and inflammation in the body. It does this by lowering the hormones responsible for the oedema (swelling). Naproxen painkillers are widely used to treat inflammatory conditions such as gout, osteoarthritis and rheumatoid arthritis, period pain, back and neck pain, tendonitis and other muscle or joint problems.
How does Naproxen work?
The way Naproxen functions is by preventing the body's cyclooxygenase (COX) enzymes from doing their job. These enzymes contribute to the production of prostaglandins, which are molecules that cause pain and inflammation when they are created at the site of injury.
By inhibiting the action of COX enzymes, prostaglandin production is reduced, which greatly lowers pain and inflammation.Choosing Between Naproxen tablets 500mg and 250mg
Wondering which Naproxen dose is right for you, 500mg or 250mg? Let's clear your doubts.
Your prescriber will tailor the Naproxen dosage based on the severity of your pain and the specific condition you're treating. In the UK, lower-dose Naproxen tablets 200mg are sometimes available over the counter for period pain, while prescription strengths such as Naproxen tablets 250mg and Naproxen tablets 500mg are used for more significant or longer-term pain.
For severe pain or chronic conditions like arthritis or back pain, your prescriber may recommend Naproxen 500mg for its stronger, longer-lasting relief.
For milder pain like headaches or muscle aches, sprains, period cramps, or dental pain, Naproxen 250mg is often sufficient.
Our prescribers will adjust the Naproxen dosage to suit individual needs while minimising side effects.
If you have never used Naproxen before, its always best to start on the lower dose first.
What Makes Naproxen Different from Other Painkillers?
Naproxen tablets are effective anti-inflammatory painkillers. They often work better than over-the-counter medications like Aspirin and Ibuprofen for inflammatory pain.
While Diclofenac and Naproxen have comparable effects, Naproxen is believed to have a lower chance of side effects.
When it comes to managing swelling and inflammation, NSAIDs like Naproxen are better suited to manage inflammation symptoms than paracetamol. While they can be used simultaneously when more pain relief is needed, Naproxen is a stronger pain reliever than paracetamol. Unlike opiate-based painkillers like codeine, Naproxen does not have the potential to become habit-forming.
Taking Naproxen with other painkillers
Naproxen tablets can be taken alongside paracetamol and opioid-type medications such as morphine, codeine, co-codamol, or tramadol.
This is because, although codeine is an opiate used solely for pain relief, Naproxen is primarily an anti-inflammatory.
It is not advisable to combine Naproxen with aspirin or other NSAIDs, such as Ibuprofen or Diclofenac tablets, as this increases the possibility of experiencing adverse effects in the stomach and intestines.For the same reason, you shouldn't take Naproxen if you take selective COX-2 inhibitors (etoricoxib, celecoxib). Although Naproxen does not thin the blood like aspirin does, it is not advised to take it with blood thinners.
It's crucial to keep in mind that Aspirin and Ibuprofen are frequently included in over-the-counter pain relievers and cures for colds and flu.
To avoid unintentional drug interactions, you should avoid taking these drugs at the same time as Naproxen. Before purchasing, look over the contents of any additional medications you want to take, or get guidance from us.
Additionally, as not everyone may use anti-inflammatory gels (such as Ibuprofen, Diclofenac, Ketoprofen, or Piroxicam) with Naproxen pills, you should consult with us before purchasing any because the amount may be excessive.
Naproxen vs. ibuprofen & diclofenac
Since Naproxen is a more potent anti-inflammatory than Ibuprofen, it is used for mild to moderate pain and inflammation or in situations when Ibuprofen has not worked.
Comparable degrees of pain relief and anti-inflammatory action are offered by Naproxen and Diclofenac. Because of worries that diclofenac can have negative effects on the heart and digestive system, Naproxen has mostly taken the place of Diclofenac in the UK. For many patients, Naproxen for pain relief provides longer-lasting control of symptoms such as arthritis, gout and period pain compared with standard over-the-counter options.Author Bio
Name Mr Suhail Jamil Role Superintendent Pharmacist GPhc Number 2069518
Directions
How to Use Naproxen Tablets
Take Naproxen as instructed by your prescriber. The lowest dose for the shortest amount of time will be provided to you.
The following are the typical doses:
For ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis, take 500mg–1g of Naproxen daily divided into two doses spaced apart by 12 hours.
Gout attack: Take 750 mg of Naproxen all at once, then 250mg every eight hours until the attack has subsided.
Painful periods and diseases of the muscles and bones: 500mg of Naproxen initially, then 250mg every 6–8 hours as needed (maximum 1250mg daily after the first dosage).
<H2> Directions for Use of Naproxen Under Certain Circumstances/Things to Avoid
Alcohol and Naproxen
When taking Naproxen tablets, you shouldn't drink alcohol because it can harm your stomach lining and increase your risk of developing gastritis, a condition with excruciating symptoms. If you drink alcohol while using Naproxen, the risk of serious stomach side effects is higher.
Additional consequences of using Naproxen with alcohol include:
- Vomit that is bloody or has a coffee-ground appearance
- Holes in the gut or stomach
- Problems with digestion or heartburn
- Stools have blood in them, or are tarry or dark in colour.
If you notice any of these, stop taking Naproxen and seek urgent medical advice.
Naproxen When Breastfeeding or Pregnant
Using Naproxen tablets while pregnant or breastfeeding is not usually advised unless recommended by a doctor. See a doctor or pharmacist for guidance if the pain you are experiencing is too great for paracetamol alone.
Blood Circulation and Naproxen
When taken over an extended period of time or if you already have heart problems, Naproxen may slightly raise your chance of having a heart attack or stroke. Naproxen should not be taken either before or after any type of cardiac surgery. Your prescriber will consider your heart and circulation history before recommending Naproxen tablets.
Your Stomach and Naproxen
Consistent usage of Naproxen may result in internal bleeding in the intestines or stomach. If left untreated, this can be serious or even life-threatening.
You should constantly be on the lookout for stomach discomfort, indigestion, blood in the stool, or dark, tarry stools when taking Naproxen. If you have any of these symptoms, get help immediately. Your prescriber may also prescribe a PPI such as Lansoprazole alongside Naproxen tablets if you are at higher risk of stomach problems.
Side Effects
Side Effects of Naproxen
As is the case with all anti-inflammatory drugs, Naproxen tablets may have side effects, especially if higher doses are taken for long periods.
Typical side effects may consist of:
- Constipation, diarrhoea, heartburn, upset stomach, and stomach discomfort are examples of gastric side effects. Gas and bloating may also be among them.
- Headache and vertigo.
- Eyesight blurriness or ear ringing.
- Skin rash and itching.
If Naproxen is taken with or after food, the likelihood of experiencing some of these side effects may decrease.
Only a very small percentage of people are susceptible to an allergic reaction to Naproxen. If you are aware of an allergy, or if you have an allergy to any other anti-inflammatory medication, such as Ibuprofen, Aspirin, or Diclofenac, you shouldn't take Naproxen.
An allergic reaction to Naproxen can include symptoms such as hives, breathing difficulties, and swelling in the face, lips, tongue, or neck. If you experience any of these symptoms, you should contact a doctor right away.
If any of these symptoms appear, you should stop taking Naproxen and visit your doctor right away:
- Pain in the chest, weakness, breathlessness, slurred speech, and issues with eyesight or balance.
Stool that is sticky, red, or black. - Spitting up blood or vomit that resembles ground coffee.
- Fast weight gain or swelling, little to no urination.
Symptoms include dark urine, clay-coloured faeces, nausea, upper stomach pain, itching, loss of appetite, and jaundice (yellowing of the skin or eyes). - Bruising, intense tingling, discomfort, numbness, and weakening in the muscles.
Fever, headache, stiff neck, chills, darker skin patches, heightened light sensitivity, and/or seizures (convulsions). - Severe skin reaction: fever, sore throat, facial or tongue swelling, burning in the eyes, and skin pain, which is followed by a rash that is red or purple, spreads, especially on the face and upper body, and blisters and peels.
Information
Summary
| Active Ingredient | Naproxen |
| Available Strengths | 250mg & 500mg |
| Drug Class | Non-Steroidal Anti-Inflammatory Drug (NSAID) |
| Naproxen Dosage | Take 250-500 mg once or twice daily as directed |
Ingredients
Each Naproxen tablet contains either 250mg or 500mg of the active ingredient (Naproxen), depending on the strength prescribed.
Naproxen ingredients
There is one active component per tablet: 250 milligrammes of Naproxen.
The following inactive substances are also present in them: Lactose, Magnesium stearate, Maize starch, Crospovidone, Propylene glycol,
Sodium hydroxide, Triethyl citrate, Titanium dioxide (E171), Potassium sorbate (E202), Sodium citrate (E331), Xanthan gum (E415),
Hydroxypropyl cellulose (E463), Purified talc (E553), and Beeswax make up the 1:1 methacrylic acid-ethyl acrylate copolymer.
Delivery
Once your order has been approved by our UK medical team it will be dispatched via Royal mail. All orders are sent using a tracked and signed for service.
Royal Mail 48 (2-5 days) | £2.49
Estimated delivery within 2-3 working days. Excludes bank holidays. Not a guaranteed service.
Free standard delivery on orders over £45.
Royal Mail 24 (1-2 days) | £2.95
Estimated delivery within 1 working day. Excludes bank holidays. Not a guaranteed service.
Royal Mail Special Delivery Guaranteed by 1pm | £6.99
Order by the 2:00 PM weekday cut-off time for guaranteed delivery by 1:00 PM the next business day.
Orders placed after the cut-off on Friday will be delivered on Tuesday.
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Written and reviewed by our qualified team
Authored by:
Mr Suhail Jamil
Superintendent Pharmacist
GPhC Number: 2069518
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